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The 2026 EASO pharmacotherapy update explicitly ranks tirzepatide above semaglutide for weight loss, while supporting semaglutide as the better-documented option for liver fibrosis endpoints in MASH [1]

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Weekly injectable medications like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro) require a single injection once per week, making the choice of day particularly important as it establishes a pattern you will follow for the duration of your treatment

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